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Younger users and men are especially prone to quitting, raising concerns since discontinuation often leads to weight regain.

Liver-directed therapies with efficacy in metabolic dysfunction-associated steatotic liver disease (MASLD), including incretin-based agents, fibroblast growth factor 21 analogs, peroxisome proliferator-activated receptor agonists, and thyroid hormone receptor beta agonists, may benefit selected MetALD patients

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It plays a crucial role in energy production and the efficient metabolism of fatty acids and amino acids

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