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Especially with active ingredients that can affect central signaling pathways and psychological factors, medical guidance, careful medical history taking, and regular follow-up monitoring are important

Statistical significance was determined using one-way ANOVA, with a significance threshold set at p 0.05)

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Moreover, it has been suggested that lean muscle mass lost during treatment with GLP1RAs may not be fully recovered after discontinuation, potentially resulting in a return to pretreatment cardiometabolic risk or a rebound risk that exceeds baseline levels [46]

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