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Once reward circuitry becomes dysregulated, dietary virtue alone cannot reset it

The average effective dose ranges from 1.0-2.4mg weekly, with higher doses associated with greater weight loss but increased side effects

First, that GLP-1s represent a breakthrough addressing one of the largest health crises in history - the obesity epidemic

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[11] A systematic review and meta-analysis found that, using randomized controlled trials, that semaglutide is efficacious for sustained weight loss in patients with overweight/obesity and without diabetes