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although several studies found improvements in steatosis and inflammation, they did not show significant changes in fibrosis 35

Effects of SGLT2 Inhibitors on Renin-Aldosterone System for One Month and Six Months in Type 2 Diabetes

However, their efficacy has limitations, particularly in patients with morbid obesity, where they may not produce enough weight loss to control or resolve the disease fully

Free Radical Biology and Medicine , 67, 396-407

Clinical trials have documented that patients who lose more than 20% of their body weight are at higher risk for hair shedding

Since GLP-1 acts on multiple pathways that are not fully addressed by other therapies, GLP-1 receptor agonists (drugs that mimic GLP-1 to improve insulin response and reduce glucose levels) have become the foundation for medications used in modern diabetes management 3