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Augmentation index normalized to 75 bpm (%) as the index of arterial stiffness, showed a tendency to decrease but unreached significance, together with the reduction of heart rate variability (HRV) and asymmetrical dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide (NO) synthesis, used for assessment of endothelial dysfunction (ED) [35]

Another limitation is the lack of data on the evolution of BMI during the follow-up period, which could affect the interpretation of our results

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Most of the drugs from plant sources are secondary metabolites, which have no role in plant metabolism

It is administered as a subcutaneous injection once weekly, with available doses of 0.75 mg, 1.5 mg, 3 mg, and 4.5 mg (Table 1)