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In a recent study, a polyGLP-1 molecule elevated TGF-1 level in bone marrow, which resulted in increased migration of BMSCs to the bone surface

Cardiovascular and Metabolic Benefits GLP-1 agonists reduce cardiovascular disease (CVD) risk factors, including hypertension, dyslipidemia, and systemic inflammation

If you lose 50+ pounds during GLP-1 therapy and started at an elevated weight, your pill may work slightly better

GLP-1 is also produced by pancreatic islet cells and neurons within the NTS of the brainstem.56 The peptide is rapidly degraded by dipeptidyl peptidase-4 into GLP-1 amide and subsequently cleared renally, resulting in a short half-life of approximately two minutes.47 Activation of the G protein-coupled GLP-1 receptor increases intracellular calcium concentrations within pancreatic islets, thereby promoting insulin exocytosis
March 18, 2021

Although overall findings support a cardioprotective effect of GLP-1 RAs, the ITCA 650 trial showed directionally higher hazard ratios for several outcomes