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doi: 10.1038/oby.2007.326

Patients with T2DM and obesity exhibit an elevated risk of adverse cardiovascular events

However, in people with reduced kidney mass, hyperfiltration can occur despite the whole-kidney GFR being in the normal range, a condition referred to as single-nephron hyperfiltration

Food and Drug Administration, but some doctors prescribe the medication "off-label" for weight loss, as is permissible Wegovy and Zepbound, which contain the same active ingredients as Ozempic and Mounjaro, respectively, are each FDA-approved as a weight loss management treatment for people with obesity, or those who are overweight with at least one related underlying condition, such as high blood pressure

Semaglutide GLP-1, Mounjaro, Wegovy, and Ozempic have varying FDA approvals for their use

Reduced-Frequency GLP1 Therapy Maintains Weight, Body Composition, and Metabolic Syndrome Improvements: A Case Series