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These are among the most commonly reported early side effects, especially during the first few days as your body adjusts to semaglutide

We thank our funders, the Novo Nordisk ISS Scheme, the National Institute for Health Research (NIHR) UCL/UCLH Biomedical Research Centre and the Sir Jules Thorne Charitable Trust, for supporting our work

The most commonly reported flu-like manifestations include: Nausea and general malaise the most frequent side effect, with incidence varying by product and dose (ranging from approximately 15-40% depending on the specific medication and dosage) Fatigue and low energy levels often described as feeling generally unwell or 'run down' Headaches ranging from mild to moderate intensity Dizziness or light-headedness particularly when standing up quickly, which may reflect dehydration or, in patients also taking insulin or sulfonylureas, possible hypoglycaemia Loss of appetite which, whilst therapeutically beneficial, can contribute to feeling unwell Mild gastrointestinal upset including occasional vomiting or abdominal discomfort These symptoms typically emerge because GLP-1 medications significantly alter gastrointestinal function and metabolic processes

Dizziness represents another recognised neurological effect, also listed as 'common' in the SmPC

In February 2023, Akums Drugs and Pharmaceuticals Limited launched Lobeglitazone, a novel treatment for type 2 diabetes in India

One such option is Endoscopic Sleeve Gastroplasty, often called ESG