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In the treatment-policy estimand analysis, at week 26 oral semaglutide (1.2% mean A1C reduction from baseline) met criteria for noninferiority when compared with liraglutide (1.1% mean A1C reduction from baseline) and met criteria for superiority when compared with placebo (0.2% mean A1C reduction from baseline
It essentially makes users lose fat and maintain muscle for most individuals
Recent systematic evaluations found no higher rate of UTIs with GLP 1 therapy compared with other diabetes medications
Oxidative stress, a key mediator of cardiovascular damage in diabetes and obesity, is significantly attenuated by GLP-1 agonists through multiple mechanisms [32]
For emergency or urgent procedures , it may not be feasible to wait for drug washout
