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Combined with the increased lipolysis (fat breakdown) and thermogenesis (fat burning), the net effect on body composition is more favorable than what either GLP-1 or GIP agonism can produce alone

Therefore, GLP-1 is save for use in T2DM and non-diabetic patients (97)

A meta-analysis [74] including the ELIXA [66], LEADER [44], SUSTAIN-6 [67], EXSCEL [68], REWIND [70], and AMPLITUDE-O [51] studies found that GLP-1RAs were associated with better renal outcomes: a 30% or 40% or more decrease in glomerular filtration rate, need for renal replacement therapy, end-stage renal failure, or death from kidney disease by 21%

As the peptides cannot survive in the stomach, they have to be injected

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