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Overweight (with a BMI of 27 kg/m2 or greater) and with at least one weight-related medical problem such as type 2 diabetes mellitus, hypertension, sleep apnea, cardiovascular disease, or dyslipidemia

Higher doses of GLP-1 analogs can themselves cause GI distress (nausea, etc.), which in an IBS patient could trigger symptom flare-ups

DY also received consulting or speaker fees from Sumitomo Dainippon Pharma, Boehringer Ingelheim, Astellas Pharma, MSD, Novo Nordisk, Ono Pharmaceutical, Eli Lilly, and Takeda Pharmaceutical

Freezing causes ice crystals to form within the solution, which physically damages the peptide structure

The SEC has opened an investigation into the company's disclosures related to these products and its broader weight loss offering

Several network meta-analyses have compared the efficacy of different GLP-1RAs.8587 Notably, the development of GLP-1RAs therapeutics is a rapidly evolving field, with novel agents, such as orforglipron, retatrutide, and cagriSema