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In the AMPLITUDE-O trial, 15% of patients included were also receiving sodium-glucose cotransporter 2 (SGLT2) inhibitors, yet efpeglenatide decreased the rate of MACE irrespective of whether patients were also receiving this treatment

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It is part of the same class of new drugs as Ozempic (semaglutide), and both medications have been widely prescribed off-label for weight loss, given the positive effect they have helping to reduce hunger, decease food intake and promote feelings of fullness

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What the Food and Drug Administration Says About Wegovy Side Effects and Appendicitis Risk The Food and Drug Administration (FDA) has not explicitly identified appendicitis as a significant risk associated with Wegovy in its official documentation and safety communications