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Looking Ahead While the evidence supporting the role of allulose in GLP-1 release and weight management is promising, further research is needed to fully understand its mechanisms of action and long-term effects

Edit to note that the chart does not include older medications such as diethylpropion, phentermine and phendimetrazine (still available) and sibutramine (no longer available)

This article reviews the efficacy and safety of different strategies to initiate and intensify basal insulin, with focus on new fixed ratio combinations of basal insulin with GLP-1 RAs available for use in a single injection pen (insulin degludec/liraglutide and insulin glargine/lixisenatide).