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Tirzepatide is not recommended for people with a family history of thyroid tumors or a family history of medullary thyroid carcinoma (MTC) and MEN2 syndrome (multiple endocrine neoplasia type 2 syndrome), as tirzepatide increases the potential risk of developing these tumors in rodents

DOI: 10.1172/JCI116186 [6] Coskun, T., Sloop, K.W., Loghin, C., et al

FDAs decision today, reiterating that the tirzepatide shortage is resolved, reflects the tireless work of our manufacturing and quality colleagues to safely expand our manufacturing capacity to bring these medicines to people who need them, an Eli Lilly spokesperson told Quartz in a emailed statement

Reports of anxiety occurred in 4.8% and 7.9% of patients treated with phentermine and topiramate extended-release 7.5 mg/46 mg and 15 mg/92 mg, respectively, compared to 2.6% of patients treated with placebo

For additional safety information, please see our Safety Page