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[DOI] [PubMed] [Google Scholar] 17.Middeldorp ME, Kamsani SH, Sanders P

For semaglutide, the molecular and pharmacological properties of the native peptide are modulated via two amino acid substitutions (at positions 8 and 34), acylation of the peptide backbone at lysine and addition of a C-18 fatty di-acid chain via an Ado-Ado-gamma-L-Glu spacer (Fig

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semaglutide, liraglutide, and dulaglutide are GLP-1-selective receptor agonists