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Other strategies developed have involved LPS-targeted antibodies (the monoclonal antibody HA.1A, or recombinant human activated protein C) or blocking LPSTLR4 pathways, however, with unsuccessful results [79]

Weeks 1 through 4: 0.5 mg once weekly Weeks 5 through 8: 1 mg once weekly Weeks 9 through 12: 2 mg once weekly Weeks 13 through 16: 4 mg once weekly Weeks 17 through 20: 6 mg once weekly Weeks 21 through 24: 8 mg once weekly Weeks 25 and beyond: 10 to 12 mg once weekly (if needed and tolerated) This protocol reaches the 8 mg therapeutic range in approximately 20 weeks

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The drug has direct effects on inflammation parameters in the kidney, and lowers fat tissue around the kidneys, lowering the amount of protein in the urine

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