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Specifically, in the extracellular half of GLP-2R, TM1 forms at least one additional helical turn, thereby moving toward TM2 (5 , measured by C of the residue at 1.33b) and bending down toward GLP-2
Furthermore, in smaller studies of patients with recent acute and advanced HF, irrespective of T2D status (62, 63), treatment with liraglutide was associated with a nonsignificant increase in CV mortality and hHF (30%, P = 0.17) (62)

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Determination of the Helix and Form of Proteins in Aqueous Solution by Circular Dichroism
