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doi: 10.1371/journal.pgph.0005516, 72 JohnsonP

Diet and lifestyle modification are necessary but not sufficient for sustained body-weight loss in the majority of individuals with obesity [84]

Limitations and Remaining Questions While semaglutide has shown significant benefits in reducing joint pain among patients with obesity, several important limitations remain: Studies often lack post-treatment follow-up, making it unclear how durable these pain and weight outcomes are once medication is stopped

Critical physicochemical properties, including particle size distribution, polydispersity, encapsulation efficiency, and surface charge, are highly sensitive to variables such as solvent conditions, raw material batches, and synthesis protocols [551]

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