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Long-Term Weight Loss & Maintenance with Semaglutide in Obesity (2022 Review of STEP Trials) consolidates findings across multiple STEP trials (1, 3, 4, 8), showing 14.917.4% mean weight loss over 68 weeks, improved cardiometabolic markers, and better quality-of-life outcomes
In preclinical models, comparison of cotadutide, a glucagon/GLP-1 dual RA, and liraglutide demonstrated superior reduction of hepatic de novo lipogenesis and enhancement of hepatocyte mitochondrial oxidative capacity (similar to levels stimulated by glucagon mono-agonismsuggesting restoration of mitochondrial function is a glucagon-specific benefit) [39]
These medications slow gastric emptying to promote satiety and support weight loss or diabetes management, but this mechanism can cause uncomfortable abdominal distension and gas
doi: 10.1016/j.molmet.2013.06.003
Examples of High-Fiber Foods: Legumes (like black beans, chickpeas), vegetables (broccoli, Brussels sprouts), and whole grains (quinoa, oats)
Most physical function tests (e.g., gait speed, Sit-to-Stand) were reliable, though some showed learning effects of 69%
