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To establish a cell model of fat overloading, palmitic (C16:0) and oleic (C18:1) acids (free fatty acids, FFAs) were added into the culture solution at a final concentration of 0.5 mM at a 1:2 ratio 22,23

Mutants and transgenic worms are listed in Supplementary Table S1

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Leng, Y., and K

Patients across North Florida are exploring tirzepatide as a non-surgical option for medically supervised weight management, including those seeking treatment in Jacksonville, Tallahassee, Gainesville, Pensacola, Daytona Beach, Ocala, and surrounding North Florida communities

In terms of its effects, it appears to impact drinking in ways (though not necessarily mechanisms) similar to naltrexone (FDA-approved) and topiramate (prescribed off label for alcohol use disorder), which have a greater effect in reducing intensity of drinking on drinking days relative to their effects on whether someone drinks at all (i.e., abstinent days) although all of them do increase abstinent days to some degree on average)