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Those without treatment interruptions reported a 17% weight loss in 12 months and 20.1% in 24 months, on average

Metformin Metformin is the recommended first-line therapy for metabolically stable children aged 10 and above with type 2 diabetes mellitus [67]

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This is surprising, since the overall incidence of gastrointestinal adverse events is much higher with the latter class (98)

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This short half-life made therapeutic use challenging for decades, until researchers began developing GIP receptor agonists and dual/triple agonists that could resist degradation or mimic its effects more efficiently