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made the analysis plan, researched data, performed analyses, contributed to the discussion and wrote the first draft of the manuscript

RAMP2 expression is shown to negatively modulate maximal inhibitory G i recruitment to the GcgR (40%), enhance maximal glucagon-stimulated cAMP production (2-fold) and potency (10-fold), improve oxyntomodulin-induced maximal cAMP production by 133%, and mediate GcgR binding promiscuity towards GLP-1R agonists when RAMP2 is not expressed [187]

2025) showed that combining semaglutide with GDF8/activin A blockers preserved lean mass and enhanced fat loss in preclinical models

E.et al (2011)