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5 For people with type 1 diabetes, there are currently no options other than insulin therapy administered as multiple daily insulin injections or via pumps

Receptor density in cardiovascular and immune tissues is, however, markedly lower than in the pancreas, and the modest physiological increment in GLP-1 produced by DPP-4 inhibition does not appear sufficient to drive the downstream signaling needed for anti-inflammatory, endothelial, or plaque-modifying effects [13], [14], [28]

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The three peptides answer different research questions: receptor selectivity studies, dual-incretin signalling, or triple-agonist energy-expenditure work
