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Initial Dose Titration and Mild Side Effects Dose titration refers to adjusting the dosage of a medication such that you get the most benefit with the least harm or fewest side effects

This gives you an objective score to compare against as treatment progresses

Weight and HbA1c changes Weight loss trajectories differed across medications (Supplementary Figs

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Tirzepatide is primarily excreted by the kidneys, so reduced renal function could theoretically affect its pharmacokinetics and efficacy (Velenosi and Urquhart, 2014)