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Yes, but context matters

The glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor both respond to tirzepatide, though with different binding affinities

[1] [4] However, refrigerated storage is preferred when possible

One encouraging data point comes from stability studies on related formulations

Tirzepatide is a glucagon-like peptide-1 (GLP-1) receptor agonist and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist, which work together to improve blood sugar control and promote weight loss in patients with type 2 diabetes

A more established pathway may involve gallbladder and biliary effects