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Elemicin: Phenylpropene derivative with mild analgesic and antiinflammatory properties, modulating TRPV1 receptors and metabolic enzymes

Ann N Y Acad Sci 1461(1):3752 Wu L, Ye S, Deng X, Fu Z, Li J, Yang C (2024) Conjugated linoleic acid ameliorates high Fat-Induced insulin resistance via regulating gut microbiota-host metabolic and immunomodulatory interactions

But, substantial opportunity remains

Insomnia is not listed among common adverse reactions in FDA prescribing information, and clinical trials did not identify it as a statistically significant side effect

In the Phase 2 trial, this approach resulted in net improvements in glycated hemoglobin and fasting glucose across all dose groups, confirming that the three receptors balance each other when introduced gradually