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Paradoxically, improved blood glucose control often reduces urination frequency

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This lack of CYP-mediated metabolism significantly reduces the potential for common drug-drug interactions, a notable advantage in patient populations that are often on multiple concomitant medications

Unfortunately cortisol always wins this fight

doi: 10.1111/j.1365-2125.2009.03381.x

The warning states that although Contrave contains bupropion, an antidepressant, Contrave is not approved to treat depression or other psychiatric disorders