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Research shows semaglutide preferentially reduces this harmful fat depot, lowering metabolic disease risk
Wayne Winegarden warns that unauthorized compounded GLP-1s are creating serious patient safety risks
However, its future trajectory is far from linear as many uncertainties remain, e.g., acceptance of obesity as a chronic disease, budget impact faced by payers and health systems willingness and ability to pay, the readout of further cardiovascular outcomes trials after the high profile results of 2023s SELECT trial for Wegovy, or new entrants challenging first generation therapies with alternative mechanisms of action (MoA) to address shortcomings such as gastrointestinal tolerability, current drugs being injectables, or the durability and quality of weight loss which distinguishes between fat and lean body mass
Retatrutide, an innovative agent, represents a potential advancement in therapy
Five scientists won this years Breakthrough Prize in Life Sciences for their work on GLP-1 and the development of drugs for diabetes and obesity.
