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Fat cells produce this hormone, so rapid weight loss may lead to drier, more fragile skin. The age profile of GLP-1/GIP users further compounds the issue of Ozempic face, notes aesthetics expert Dr Glyn Estebanez, one of Allergans practitioner trainers

Other weight-loss drugs are currently in development or regulatory approval stages, including: Once-daily GLP-1 pill orforglipron (Eli Lilly), which, when taken alongside a healthy diet and exercise, resulted in a 7.5% weight loss over 72 weeks on the 6mg dose, 8.4% loss with 12mg of orforglipron, and 11.2% loss with 36mg of orforglipron, as compared with 2.1% loss with placebo (funded by Eli Lilly

PLoS One 11:e0149549 Seino Y, Ogata H, Maekawa R et al (2015) Fructose induces glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 and insulin secretion: role of adenosine triphosphate-sensitive K + channels

Administration of GLP-1 analogs (or DPP-4 inhibitors, which inhibit the degradation of GLP-1), decreased cardiovascular and thrombotic complications in animal models of LPS-induced sepsis