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& Wilke, R

66 (Tables 1 and 2) Current GLP-1RAs GLP-1RAs are synthetic protein preparations that have partial or complete amino acid sequence homology with GLP-1 found in the body, are not easily degraded, have longer half-lives and have stronger biological activity

is an associate editor of the Journal of Prevention of Alzheimers Disease and Alzheimers and Dementia: Diagnosis, Assessment and Disease Monitoring

27 Hence, using Ile 12 in tirzepatide seems not to weaken its GLP-1 activity and to strengthen its GIP activity

139 Liraglutide also rescued the deleterious effects of a high-fat diet on hippocampal LTP of neurotransmission 140 and enhanced the number of hippocampal and cortical synapses in AD model mice

Its ability to tackle obesity, insulin resistance, and metabolic dysfunction is groundbreaking