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For anyone testing the waters before committing, the makers highlight their trial pathways as a way to reduce uncertainty

doi: 10.1210/jc.2006-0587

Research published in the New England Journal of Medicine and subsequent body composition sub-analyses from the STEP trials have begun to quantify this more precisely

(2015) 94:e647
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Introduction Obesity is a global health problem and increases the risk of developing type II diabetes mellitus (T2DM), cardiovascular disease, and dyslipidemia
