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What Makes Semaglutide So Effective for Weight Management

#iHeardSTL #GLP1 #WeightLossDrugs

Nakamura T, Tanimoto H, Mizuno Y et al (2018) Gastric inhibitory polypeptide receptor antagonist, SKL-14959, suppressed body weight gain on diet-induced obesity mice

Lipid improvements typically become apparent within 12-20 weeks of initiating GLP-1 receptor agonist therapy, paralleling the weight loss trajectory

REDEFINE 2: Data in Type 2 diabetes populations Superresponders: ~40% of participants in REDEFINE 1 lost 25% body weight Completion rates: Generally favorable, suggesting acceptable tolerability The 22.7% mean figure is extraordinary on its own higher than semaglutide 2.4mg alone (~15% in STEP trials) and higher than tirzepatide alone (~21% in SURMOUNT-1)

Sleep disruption could inhibit the drugs actions as well, as poor sleep is shown to delay the release of the bodys natural GLP-1 hormone