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The most striking protective effects of SGLT2is were a marked reduction in hospitalization for heart failure and a remarkable reduced progression of chronic kidney disease

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Novo Nordisk Internet

Upon binding to GLP-1, GLP-1R initiates a cascade of events, starting from activation of adenyl cyclase and cyclic adenosine monophosphate (cAMP) production, which rapidly potentiates glucose-dependent insulin release

GLP-1R agonists also demonstrate neuroprotective effects, including reduction of neuroinflammation, oxidative stress, and neuronal apoptosis, with emerging evidence for benefit in neurodegenerative diseases such as Parkinsons and Alzheimers disease [75, 76]