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[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Bae JH

Pharmacologic Implications DPP-4 inhibitors comprise a class of non-insulin anti-diabetic therapeutic interventions that enhance insulin secretion by pancreatic -cells and act by blocking the enzymatic action of DPP-4

FIGURE 5 2.4.1 Vascular remodeling In DR, the RhoA/ROCK signaling pathway is activated by high glucose, which leads to endothelial dysfunction, breakdown of the blood-retinal barrier (BRB), and capillary leakage

Individuals with obesity, both with and without T2DM, show increased risks for gastrointestinal bleeding when treated with GLP-1R agonists combined with aspirin [140]

treatment F (1,13) = 5.609, p = 0.034