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"Wegovy injections are considered slightly more effective than the tablet," says Bradshaw

Semaglutide vs Tirzepatide: Comparing Weight-Loss Injections Semaglutide vs tirzepatide is a common comparison because both are weekly injectable medicines used to support weight loss alongside diet and lifestyle changes

Am J Physiol Gastrointest Liver Physiol (2013) 304:G111727

The pain reduction going from 28G to 31G is meaningful over the course of a long treatment protocol measured in months

I suspect this is from the glucagon agonism of the drug as glucagon stimulates the formation of extra bile acids/bile salts in the liver which can be very irritating to the intestinal lining causing diarrhea
NICE recommends GLP-1 receptor agonists for type 2 diabetes when metformin and other oral medications fail to achieve adequate glycaemic control, particularly with BMI 35 kg/m or weight-related comorbidities
