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Preclinical studies have evaluated the therapeutic potential of GLP-1 based polypharmacology for the treatment of obesity and diabetes
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In some brain regions, GLP-1 receptor activation triggers both effects, but in others, like the hippocampus or the ventral tegmental area, food intake reduction occurs without nausea
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Current evidence suggests minimal milk transfer of GLP-1 peptides, but formal safety studies in nursing mothers do not exist
