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Following in vitro tests, compound 57 (Figure 7) was shown to be the most potent DPP-4 inhibitor, with an IC 50 of 0.87 nM

Indeed, after 60 min of the glucose challenge, and therefore 65 min after dosing, 1 showed no more significant effect compare to the vehicle while 14 was still active, as expected from the blood glucose study (Fig
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Top 5 Best Fiber Supplements for GLP-1 Constipation Dietary fiber has been touted as a means of smoothing out digestion long before GLP-1s came into vogue

No association was found (p = 0.812

Diabetologia 60, 15861593
