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doi: 10.1371/journal.pone.0100778
Collectively, such findings are remarkable in that they suggest a new strategy in which the co-existing metabolic disorders of type 2 diabetes and obesity will be treatable using a single peptide such as EP45 that lowers levels of blood glucose by virtue of its GLP-1R-mediated effect, while simultaneously suppressing appetite by virtue of its NPY2R-mediated effect

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Despite its relatively short half-life (2 4 hours), lixisenatide is recommended for once-daily dosing in the treatment of T2DM [ Table 2 ]

Without a structured maintenance plan, most patients regain 5070% of lost weight within 12 months of stopping

doi: 10.1007/BF01852257
