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Glucose Stimulated Insulin Secretion (GSIS) For in vitro static GSIS, digestion and islet isolation was performed as previously described 1, 15, 16 for each condition

Mechanism of action GLP-1 Receptor Activation: Insulin Release: Activation of GLP-1 receptors stimulates glucose-dependent insulin secretion from pancreatic -cells, thereby enhancing postprandial glycemic regulation