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The FDA has approved a drug treatment for chronic weight management for the first time since 2014.

This Review summarizes the available data about combination immunotherapies in T1DM, particularly addressing their clinical importance.

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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis