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Even a modest fragment library of 1000 compounds could generate 1000^3 (1 billion) possible adducts after just 3 cycles
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It is not suitable for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Considering dopamines pivotal role in the brains reward system, such alterations could lead to an imbalance in dopaminergic neurotransmission 43,44
