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Yes anabolic steroids, testosterone misuse, some supplements, and certain medications can increase estrogen levels and trigger gynecomastia

JAMA 1990;263(21): 28932898

Obesity-associated adipose tissue thus functions as an inflammatory endocrine organ, particularly in visceral tissue producing TNF-, IL-6, IL-1, Monocyte chemoattractant Protein 1 (MCP-1, which is associated with tamoxifen resistance), and leptin while reducing adiponectin (an anti-inflammatory adipokine) levels, thereby promoting chronic low-grade inflammation, insulin resistance, and tumor-promoting signaling pathways

Studies on long-term semaglutide use (Wegovy) Wegovy is the higher-strength version of semaglutide that is FDA-approved for weight loss

doi: 10.1016/S0140-6736(19)31271-1 [DOI] [PubMed] [Google Scholar] 10

Clinical data shows tirzepatide produces approximately 35% greater weight loss than semaglutide at comparable treatment durations, achieved through superior receptor coverage rather than medication multiplication