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N Engl J Med 2022;387:20516.ArticlePubMed 19

Mozaffarian D et al

Men who rely solely on tirzepatide for weight loss, without resistance training, lose significantly more muscle than those who lift

Exclusion criteria were a history of bariatric surgery, alcohol use disorder identification test (AUDIT) greater than 16, hemoglobin A1c measurement greater than 9, a history of seizure disorder or traumatic brain injury, on specific medications that interfere with alcohol metabolism such as certain antibiotics (reviewed on a case-by-case basis by study physician), or currently pregnant or lactating

Signs of severe allergic reaction : facial swelling, difficulty breathing, or widespread rash