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Serious / Rare Side Effects Angioedema rare but life-threatening (less common than ACE inhibitors) Acute kidney injury especially in patients with bilateral renal artery stenosis Hyperkalemia requires monitoring 5

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ACE inhibitor (ACE-I)-induced angioedema, with an underreported incidence of 0.10.7%, manifests as non-pitting oedema of subcutaneous and submucosal tissues

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Tirzepatide's dual GLP-1/GIP mechanism may offer greater potency in some patients, but individual genetic predispositions and biomarkers significantly influence treat