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They also act on the appetite centers in the brain, significantly reducing hunger and what is often called food noise. The dual-action drug tirzepatide works on both GLP-1 and GIP receptors, often leading to even greater efficacy

Kidney disease and obesity: epidemiology, mechanisms and treatment

I explore the research on GLP-1s and Alzheimers here

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Furthermore, advanced glycation end products activate vascular endothelial growth factor (VEGF), which increases matrix metalloproteinase synthesis and alters tight junction proteins

Evidence Builds The SURMOUNT-OSA trial, funded by Eli Lilly, added to this evidence
