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elegans have demonstrated that the removal of germline stem cellseither through laser ablation or genetic mutations, such as the temperature-sensitive glp-1(e2144) mutantleads to lifespan extension and significant alterations in fat metabolism in hermaphrodites 2,6,12

Mechanisms of weight regain after weight loss-the role of adipose tissue
Sedentary patients who are not performing resistance training lose both the osteogenic stimulus that weight-bearing exercise provides and the muscle mass that protects joints
Sorensen et al., 2015

Sources Koenig, W., Sund, M., Frhlich, M., Fischer, H