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The first few weeks of treatment are when fatigue is most common, as your body adjusts to metabolic and digestive changes caused by the medication

In other words, don't give up on Pfizer because it doesn't have a GLP-1 drug just yet

17 Rosenstock, J., et al., Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial

Mounjaro PA is similar, with the SURPASS trial program as the reference

The Tirzepatide (Zepbound) segment is expected to grow at the fastest rate during the forecast period due to its dual-action mechanism, targeting both GLP-1 and GIP receptors, which enhances weight loss outcomes

The prolongation of apparent half-life with multiple dosing is characteristic of drugs that undergo distribution into deep tissue compartments from which elimination is slow, creating a multi-exponential elimination profile