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Many neuroprotective effects remain to be causally associated with anti-inflammatory mechanisms, and some Alzheimers disease mouse models did not respond to semaglutide or tirzepatide, emphasizing that not all neural benefits are consistent across studies

The company made this prediction on the timing of FDA approval as it announced top-line results of a Phase 3 study showing a nearly 16% overall weight loss over a 17-month period among people who have both Type 2 diabetes and obesity 1

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These therapies do not typically cause hypoglycemia on their own but may occur when used in combination with additional glycemic drugs
doi: 10.1210/en.2008-0180 [DOI] [PubMed] [Google Scholar] 44.Sandoval DA, Bagnol D, Woods SC, et al

2021;3:fcab202
