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PLOS Medicine

Diarrhea Diarrhea can cause water loss and electrolyte imbalance in the body

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[DOI] [PubMed] [Google Scholar] Astorino TA, Schubert MM (2018) Changes in fat oxidation in response to various regimes of high intensity interval training (HIIT)
Serious adverse events are rare and usually occur at very high doses

The combination of a medication that slows digestion with a disease that already disrupts GI function creates potential for worsening obstruction, nausea, or inflammatory flares
