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The structure shows that important hydrophobic ligand-receptor interactions are conserved in agonist- and antagonist-bound forms of the extracellular domain, but certain residues in the ligand-binding site adopt a GLP-1-specific conformation

234 Winding, C

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In January, the Reimbursement Committee recommended that Danes with type 2 diabetes should not receive reimbursement for diabetes medicines of the GLP-1 analog type, which primarily consists of Ozempic

This stratified approach avoids the one-size-fits-all assumptions that have constrained past indication extension attempts and provides a clearer, evidence-led path to expanding GLP-1 use where it is biologically and clinically justified.